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Org Biomol Chem. 2013 Sep 25;11(40):6919-28. doi: 10.1039/c3ob41483c.

Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor.

Abstract

An efficient catalytic one-pot synthesis of TBDMS-protected diacylglycerols has been developed, starting from enantiopure glycidol. Subsequent migration-free deprotection leads to stereo- and regiochemically pure diacylglycerols. This novel strategy has been applied to the synthesis of a major Mycobacterium tuberculosis phospholipid, its desmethyl analogue, and platelet activating factor.

PMID:
24191360
DOI:
10.1039/c3ob41483c
[Indexed for MEDLINE]

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