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Toxicol Pathol. 2014 Jan;42(1):207-16. doi: 10.1177/0192623313509907. Epub 2013 Nov 3.

Overview of exocrine pancreatic pathobiology.

Author information

1
1Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA.

Abstract

Exocrine pancreas is a source of several enzymes that are essential for the digestive process. The exocrine pancreatic secretion is tightly regulated by the neuroendocrine system. The endocrine pancreas is tightly integrated anatomically and physiologically with the exocrine pancreas and modulates its function. Compound-induced pancreatitis is not a common event in toxicology or drug development, but it becomes a significant liability when encountered. Understanding the species-specific differences in physiology is essential to understand the underlying pathobiology of pancreatic disease in animal models and its relevance to human disease. This review will mainly focus on understanding the morphology and physiology of the pancreas, unique islet-exocrine interactions, and pancreatitis.

KEYWORDS:

animal models; digestive system; endocrine system.

PMID:
24190915
PMCID:
PMC4360889
DOI:
10.1177/0192623313509907
[Indexed for MEDLINE]
Free PMC Article

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