Format

Send to

Choose Destination
See comment in PubMed Commons below
Phytochemistry. 2013 Dec;96:214-22. doi: 10.1016/j.phytochem.2013.10.006. Epub 2013 Nov 1.

Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz.

Author information

1
School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, PR China.

Abstract

Phytochemical investigation of Inula wissmanniana Hand.-Mazz. afforded 21 eudesmane and germacrane derivatives, including rare 4,5-secoeudesman-12,5-olide, eudesman-12,5-olide, 3,4-secoeudesman-12-oic acid, and germacra-4-en-12,6-olides. Their structures were elucidated by combinative analyses of MS, NMR, electronic circular dichroism, and X-ray crystallography data. Moreover, most of the isolates exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages and cytotoxicity in HepG2, PC-3, and MGC-803 tumor cells.

KEYWORDS:

Asteraceae; Cytotoxicity; Eudesmane; Germacrane; Inula wissmanniana Hand.-Mazz.; NO production

PMID:
24189347
DOI:
10.1016/j.phytochem.2013.10.006
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center