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Emerg Infect Dis. 2013 Nov;19(11):1843-6. doi: 10.3201/eid1911.121407.

Evidence of vaccine-related reassortment of rotavirus, Brazil, 2008-2010.

Abstract

Analysis of 27 rotavirus strains from vaccinated and unvaccinated children revealed reassortment events in 3 strains: a gene derived from a vaccine; a gene acquired from a circulating strain; and reassortment between circulating strains. Data suggest that the widespread use of this monovalent rotavirus vaccine may introduce vaccine genes into circulating human rotaviruses or vice versa.

KEYWORDS:

Brazil; G1P[8] strains; RVA; Rotarix; phylogenetic analysis; reassortment; rotavirus; vaccine; viruses

PMID:
24188273
PMCID:
PMC3837663
DOI:
10.3201/eid1911.121407
[Indexed for MEDLINE]
Free PMC Article

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