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Climacteric. 2014 Aug;17(4):325-35. doi: 10.3109/13697137.2013.861814. Epub 2013 Dec 27.

Hypericum perforatum L. preparations for menopause: a meta-analysis of efficacy and safety.

Author information

1
* School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang.

Abstract

OBJECTIVE:

To compare by meta-analysis the efficacy and adverse events of Hypericum perforatum L. (St. John's Wort), or its combinations, and placebo for menopausal women.

DESIGN:

A systematic review and meta-analysis were carried out by searching in Pubmed, Cochrane Library, Embase and the Web of Science database.

RESULTS:

Extracts of Hypericum perforatum L. and its combination with herbs were significantly superior to placebo (standard mean difference = -1.08; 95% confidence interval -1.38 to -0.77); extracts of Hypericum perforatum L. proved to be more effective than placebo in the treatment of menopause. Adverse events occurred in 53 (17.4%) patients on Hypericum perforatum L. preparations and 45 (15.4%) patients on placebo (relative risk = 1.16; 95% confidence interval 0.81-1.66).

CONCLUSION:

Extracts of Hypericum perforatum L. have possibly fewer side-effects than placebo for the treatment of menopausal women.

KEYWORDS:

EFFICACY; HYPERICUM PERFORATUM L; MENOPAUSE; META-ANALYSIS; SAFETY

PMID:
24188229
DOI:
10.3109/13697137.2013.861814
[Indexed for MEDLINE]

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