Send to

Choose Destination
See comment in PubMed Commons below
Yao Xue Xue Bao. 2013 Aug;48(8):1195-208.

[Application of methyl in drug design].

[Article in Chinese]

Author information

School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.


The methyl group plays an important role in the rational drug design. Introducing methyl into small molecules has become an important strategy of lead compound optimization. The application of methyl in drug design is reviewed in this paper. Methyl can modulate the physicochemical, pharmacodynamic, and pharmacokinetic properties by ortho effect, inductive effect, and conformational effect. It also improves the metabolic stability as a soft metabolic point. In addition, introducing methyl into drug molecules can also be applied as a strategy in new uses of old drugs and generate me-too drugs.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center