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Nat Methods. 2013 Dec;10(12):1192-5. doi: 10.1038/nmeth.2724. Epub 2013 Nov 3.

Accelerated discovery via a whole-cell model.

Author information

1
1] Department of Bioengineering, Stanford University, Stanford, California, USA. [2].

Abstract

To test the promise of whole-cell modeling to facilitate scientific inquiry, we compared growth rates simulated in a whole-cell model with experimental measurements for all viable single-gene disruption Mycoplasma genitalium strains. Discrepancies between simulations and experiments led to predictions about kinetic parameters of specific enzymes that we subsequently validated. These findings represent, to our knowledge, the first application of whole-cell modeling to accelerate biological discovery.

PMID:
24185838
PMCID:
PMC3856890
DOI:
10.1038/nmeth.2724
[Indexed for MEDLINE]
Free PMC Article
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