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Nat Med. 2013 Dec;19(12):1667-72. doi: 10.1038/nm.3390. Epub 2013 Nov 3.

Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging.

Author information

1
Department of Psychology, Stanford University, Stanford, California, USA.

Abstract

Here, we describe a quantitative neuroimaging method to estimate the macromolecular tissue volume (MTV), a fundamental measure of brain anatomy. By making measurements over a range of field strengths and scan parameters, we tested the key assumptions and the robustness of the method. The measurements confirm that a consistent quantitative estimate of MTV can be obtained across a range of scanners. MTV estimates are sufficiently precise to enable a comparison between data obtained from an individual subject with control population data. We describe two applications. First, we show that MTV estimates can be combined with T1 and diffusion measurements to augment our understanding of the tissue properties. Second, we show that MTV provides a sensitive measure of disease status in individual patients with multiple sclerosis. The MTV maps are obtained using short clinically appropriate scans that can reveal how tissue changes influence behavior and cognition.

PMID:
24185694
PMCID:
PMC3855886
DOI:
10.1038/nm.3390
[Indexed for MEDLINE]
Free PMC Article

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