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Virulence. 2014 Jan 1;5(1):66-72. doi: 10.4161/viru.26907. Epub 2013 Nov 1.

The role of mitochondrial dysfunction in sepsis-induced multi-organ failure.

Author information

1
Bloomsbury Institute of Intensive Care Medicine; University College London; London, UK.

Abstract

An important role for bioenergetic dysfunction is increasingly emerging to potentially explain the paradox of clinical and biochemical organ failure in sepsis yet minimal cell death, maintained tissue oxygenation and recovery in survivors. Associations are well-recognized between the degree of mitochondrial dysfunction and outcomes. While this does not confirm cause-and-effect, it does nevertheless suggest a new route for therapeutic intervention focused on either mitochondrial protection or acceleration of the recovery process through stimulation of mitochondrial biogenesis (new protein turnover). This is particularly pertinent in light of the multiple trial failures related to immunomodulatory therapies. This overview will provide insights into mitochondrial biology, the relevance to sepsis, and therapeutic opportunities that possibly emerge.

KEYWORDS:

biogenesis; mitochondria; mitophagy; multi-organ failure; nitric oxide; reactive oxygen species; sepsis

PMID:
24185508
PMCID:
PMC3916385
DOI:
10.4161/viru.26907
[Indexed for MEDLINE]
Free PMC Article

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