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Antiviral Res. 2014 Jan;101:57-61. doi: 10.1016/j.antiviral.2013.10.014. Epub 2013 Nov 1.

Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus.

Author information

1
Department of Virology, University Hospital, Grenoble, France; Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, B.P. 181, 6, rue Jules Horowitz, 38042 Grenoble Cedex 9, France. Electronic address: rgermi@chu-grenoble.fr.
2
Department of Infectious diseases, University Hospital, Grenoble, France.
3
Department of Virology, French National Cytomegalovirus Reference Center, University Hospital, Limoges, France.
4
Department of Virology, University Hospital, Grenoble, France; Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, B.P. 181, 6, rue Jules Horowitz, 38042 Grenoble Cedex 9, France.
5
Department of Hematology, University Hospital, Grenoble, France.
6
Department of Virology, University Hospital, Grenoble, France; Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, B.P. 181, 6, rue Jules Horowitz, 38042 Grenoble Cedex 9, France; Department of Infectious diseases, University Hospital, Grenoble, France.
7
Department of Pneumology, University Hospital, Grenoble, France.
8
Department of Nephrology, University Hospital, Grenoble, France.

Abstract

Cytomegalovirus (CMV) strains resistant to ganciclovir, cidofovir and/or foscarnet were genotypically and phenotypically characterised in two haematopoietic stem cell transplant recipients and three solid-organ transplant recipients with CMV disease. The anti-malaria drug artesunate led to a favourable virological and clinical response in three cases with mild CMV diseases (fever and neutropaenia) but was ineffective in two fatal CMV diseases with lung involvement in spite of a decrease in the CMV DNA load in blood and bronchoalveolar fluid.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01008540.

KEYWORDS:

Artesunate; Cytomegalovirus; Multidrug resistance; Transplantation

PMID:
24184983
DOI:
10.1016/j.antiviral.2013.10.014
[Indexed for MEDLINE]

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