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Chem Biol. 2013 Nov 21;20(11):1323-8. doi: 10.1016/j.chembiol.2013.08.010. Epub 2013 Oct 31.

Targeting mitochondrial DNA with a platinum-based anticancer agent.

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  • 1Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada.

Abstract

An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.

Copyright © 2013 Elsevier Ltd. All rights reserved.

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