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Cancer Lett. 2014 Mar 28;344(2):188-94. doi: 10.1016/j.canlet.2013.10.023. Epub 2013 Oct 30.

Differential miRNA expression in repeated recurrence of nasopharyngeal carcinoma.

Author information

1
Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan.
2
Department of Otolaryngology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
3
Department of Pathology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
4
Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan, Taiwan; Center for Nanotechnology, Chung Yuan Christian University, Taoyuan, Taiwan.
5
Research Center of Excellence for Environment Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Dermatology, Kaohsiung Medical University, Kaohsiung, Taiwan.
6
Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan; Department of Life Sciences, Tzu-Chi University, Hualien, Taiwan. Electronic address: jwlee@mail.tcu.edu.tw.

Abstract

Deregulated microRNAs (miRNAs) are known to be involved in the tumorigenesis of nasopharyngeal carcinoma (NPC). However, the role of miRNA expression in tumor recurrence is not yet understood. We found distinctive miRNA expression in repeated recurrent tumors using miRNA microarray, and verified this using quantitative real-time RT-PCR and miRNA in situ hybridization analysis. Computational analysis and immunohistochemistry further revealed that differentially expressed miRNAs may work in concert to modulate a multitude of biological pathways. The results not only indicate differential miRNA expression during tumor relapse, but imply the potential use of miRNAs to classify repeated recurrence of NPC beyond the histological approach.

KEYWORDS:

MicroRNA; Nasopharyngeal carcinoma; Recurrence

PMID:
24183849
DOI:
10.1016/j.canlet.2013.10.023
[Indexed for MEDLINE]
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