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Neuron. 2013 Oct 30;80(3):751-64. doi: 10.1016/j.neuron.2013.10.002.

Scaling brain size, keeping timing: evolutionary preservation of brain rhythms.

Author information

1
The Neuroscience Institute, Center for Neural Science, School of Medicine, New York University, New York, NY 10016, USA. Electronic address: gyorgy.buzsaki@nyumc.org.

Abstract

Despite the several-thousand-fold increase of brain volume during the course of mammalian evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for multiple-time-scale communication within and across neuronal networks at approximately the same speed, irrespective of brain size. Deployment of large-diameter axons of long-range neurons could be a key factor in the preserved time management in growing brains. We discuss the consequences of such preserved network constellation in mental disease, drug discovery, and interventional therapies.

PMID:
24183025
PMCID:
PMC4009705
DOI:
10.1016/j.neuron.2013.10.002
[Indexed for MEDLINE]
Free PMC Article

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