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Phytomedicine. 2014 Feb 15;21(3):379-82. doi: 10.1016/j.phymed.2013.09.009. Epub 2013 Oct 29.

Urease inhibitory activity of ursane type sulfated saponins from the aerial parts of Zygophyllum fabago Linn.

Author information

1
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: saleha_iccs@yahoo.com.
2
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
3
Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. Electronic address: afsarhej@yahoo.com.
4
Department of Biochemistry, Shankar Campus, Abdul Wali Khan University, Mardan, Pakistan.
5
Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
6
Pharmaceutical Division, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi 75280, Pakistan.
7
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: vuahmad@hotmail.com.
8
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara 06330, Turkey.

Abstract

Five ursane type sulfated saponins have been isolated from the aerial parts of Zygophyllum fabago Linn. (locally called Chashum). The urease inhibitory effects of these compounds have been investigated for the first time as well as their molecular docking studies have also been carried out to check the structure-activity relationship. The IC50 values of these compounds could not be found due to paucity of the samples. The molecular docking studies were performed only for the most active compound mono sodium salt of 3β,23-di-O-sulfonyl-23-hydroxyurs-20(21)-en-28-oic acid 28-O-[β-D-glucopyranosyl] ester (Zygofaboside A; 1).

KEYWORDS:

Molecular docking; Sulfated saponins; Urease inhibitory activity; Ursane; Zygophyllum fabago

PMID:
24182987
DOI:
10.1016/j.phymed.2013.09.009
[Indexed for MEDLINE]
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