Format

Send to

Choose Destination
See comment in PubMed Commons below
Rheum Dis Clin North Am. 2013 Nov;39(4):735-49. doi: 10.1016/j.rdc.2013.05.002. Epub 2013 Aug 17.

Autoinflammatory bone diseases.

Author information

1
Division of Immunology, Rheumatology, and Allergy, Department of Pediatrics, University of Utah, PO Box 581289, Salt Lake City, UT 84158, USA. Electronic address: Sara.Stern@hsc.utah.edu.

Abstract

Autoinflammatory bone disease is a new branch of autoinflammatory diseases caused by seemingly unprovoked activation of the innate immune system leading to an osseous inflammatory process. The inflammatory bone lesions in these disorders are characterized by chronic inflammation that is typically culture negative with no demonstrable organism on histopathology. The most common autoinflammatory bone diseases in childhood include chronic nonbacterial osteomyelitis (CNO), synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, Majeed syndrome, deficiency of interleukin-1 receptor antagonist, and cherubism. In this article, the authors focus on CNO and summarize the distinct genetic autoinflammatory bone syndromes.

KEYWORDS:

Autoinflammatory bone diseases; CRMO; Cherubism; Chronic nonbacterial osteomyelitis; DIRA; Majeed syndrome; SAPHO syndrome

PMID:
24182852
PMCID:
PMC3823499
DOI:
10.1016/j.rdc.2013.05.002
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center