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Am J Kidney Dis. 2014 Feb;63(2):236-43. doi: 10.1053/j.ajkd.2013.08.028. Epub 2013 Oct 30.

Association of kidney disease outcomes with risk factors for CKD: findings from the Chronic Renal Insufficiency Cohort (CRIC) study.

Author information

1
University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address: weiyang@mail.med.upenn.edu.
2
University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
3
University of Utah, Salt Lake City, UT.
4
University of California at San Francisco, San Francisco, CA.
5
University of Maryland, Baltimore, MD.
6
Tulane University, New Orleans, LA.
7
University of Illinois at Chicago, Chicago, IL.
8
University of Michigan, Ann Arbor, MI.
9
Case Western Reserve University, Cleveland, OH.
10
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.

Abstract

BACKGROUND:

Various indicators of progression of chronic kidney disease (CKD) have been used as outcomes in clinical research studies. The effect of using varying measures on the association of risk factors with CKD progression has not been well characterized.

STUDY DESIGN:

Prospective cohort study.

SETTING & PARTICIPANTS:

The Chronic Renal Insufficiency Cohort (CRIC) Study (N=3,939) enrolled men and women with mild to moderate CKD, 48% of whom had diabetes and 42% were self-reported black race.

PREDICTORS:

Age, race, sex, diabetes, baseline estimated glomerular filtration rate (eGFR), proteinuria, and other established CKD risk factors.

OUTCOMES:

Death, end-stage renal disease (ESRD), and eGFR events, including: (1) eGFR halving, (2) eGFR<15mL/min/1.73m(2), (3) eGFR halving and <15mL/min/1.73m(2), (4) eGFR decrease of 20mL/min/1.73m(2), (5) eGFR halving or decrease of 20mL/min/1.73m(2), and (6) eGFR decrease of 25% and change in CKD stage.

RESULTS:

Mean entry eGFR was 44.9mL/min/1.73m(2). Annual rates of death, ESRD, and eGFR halving were 2.5%, 4.0%, and 6.1%, respectively, during an average follow-up of 5.4 years. Associations between risk factors and ESRD and eGFR events were similar across different definitions. However, these associations were substantially different from those with death. HRs for ESRD, eGFR halving, and death in the highest compared to the lowest proteinuria category were 11.83 (95% CI, 8.40-16.65), 11.19 (95% CI, 8.53-14.68), and 1.47 (95% CI, 1.10-1.96), respectively.

LIMITATIONS:

Participants may not be representative of the entire CKD population.

CONCLUSIONS:

Using ESRD or eGFR events, but not death, in the definition of kidney disease outcomes is appropriate in follow-up studies to identify risk factors for CKD progression.

KEYWORDS:

Chronic Renal Insufficiency Cohort (CRIC); Kidney disease progression; chronic kidney disease (CKD); decreased estimated glomerular filtration rate (eGFR); disease trajectory; end-stage renal disease (ESRD); estimated glomerular filtration rate (eGFR); longitudinal outcome; mortality risk; renal function

PMID:
24182662
PMCID:
PMC3946885
DOI:
10.1053/j.ajkd.2013.08.028
[Indexed for MEDLINE]
Free PMC Article

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