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J Affect Disord. 2014 Jan;152-154:268-76. doi: 10.1016/j.jad.2013.09.024. Epub 2013 Oct 5.

Cognitive Behavioural Analysis System of Psychotherapy (CBASP) for chronic depression: clinical characteristics and six month clinical outcomes in an open case series.

Author information

1
Division of Neuroscience, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, UK. Electronic address: johnswan@nhs.net.

Abstract

BACKGROUND:

Evidence-based guidance on how best to treat chronic depression is limited. Cognitive Behavioural Analysis System of Psychotherapy (CBASP) has shown some promise with this 'difficult-to-treat' clinical group. This case series was designed to assess the acceptability and utility of this novel treatment in routine clinical practice within the U.K. National Health Service.

METHODS:

We offered an open trial of CBASP to a cohort of 115 referred patients within primary and secondary care. Diagnostic interview and standardised outcome measures were administered before and after 6 months of CBASP with a trained, accredited therapist.

RESULTS:

Seventy-four patients entered therapy, with 46 completing. 30% met criteria for remission (≤ 8 HRSD-24 score) and a further 30% met criteria for clinically significant change (> 8 and ≤15 HRSD-24 plus 50% reduction in baseline score). Thirty-nine per cent made "No change". Group measures of quality of life, social functioning and interpersonal functioning also improved.

LIMITATIONS:

This was an open study design with a moderate sample size and no control group. Ratings were not completed using a blinded procedure.

CONCLUSIONS:

CBASP is an acceptable therapy for a large proportion of patients with chronic depression and was associated with clinically significant change in 60% of completers.

KEYWORDS:

CBASP; Case series; Chronic depression; Psychotherapy; Treatment-refractory

PMID:
24182417
DOI:
10.1016/j.jad.2013.09.024
[Indexed for MEDLINE]

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