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J Allergy Clin Immunol. 1986 Jan;77(1 Pt 1):43-8.

Lack of correlation between titers of serum allergen-specific IgE and symptoms in untreated patients with seasonal allergic rhinitis.


In five ragweed seasons and three grass pollen seasons, preseason and postseason ragweed-specific serum IgE and nasal secretory-specific IgE and IgA have been measured in untreated patients with seasonal allergic rhinitis. There was no consistent correlation between severity of rhinitis, as measured by symptom/medication scores during the season, and either absolute or changes in antibody titers. These findings suggest that antibody levels are only one of the factors that determine symptom severity.

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