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ACS Chem Biol. 2014 Jan 17;9(1):111-5. doi: 10.1021/cb400755b. Epub 2013 Nov 8.

General method for regulating protein stability with light.

Author information

  • 1Department of Chemical & Systems Biology, Stanford University , Stanford California, 94305, USA.

Abstract

Post-translational regulation of protein abundance in cells is a powerful tool for studying protein function. Here, we describe a novel genetically encoded protein domain that is degraded upon exposure to nontoxic blue light. We demonstrate that fusion proteins containing this domain are rapidly degraded in cultured cells and in zebrafish upon illumination.

PMID:
24180414
PMCID:
PMC3906921
DOI:
10.1021/cb400755b
[PubMed - indexed for MEDLINE]
Free PMC Article
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