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Drug Chem Toxicol. 2014 Jul;37(3):261-7. doi: 10.3109/01480545.2013.838780. Epub 2013 Nov 4.

Oral intralipid emulsion use: a novel therapeutic approach to pancreatic β-cell injury caused by malathion toxicity in rats.

Author information

1
Department of Anesthesiology and Reanimation .

Abstract

We aimed to investigate whether oral intralipid emulsion (OIE) reduces pancreatic β-cell injury (PβCI) by chelating with malathion (M), or increases PβCI by increasing M absorption in the stomach. Fifty rats were randomly divided into six groups: control group (C); OIE administered group (L); M-treated group (M); OIE-administered group immediately after given M (M0L); OIE-administered group 6 hours after being given M (M6L) and OIE administered group 12 hours after being given M (M12L). M induced PβCI, hyperglycemia, temporary hyperinsulinemia and oxidative stress (OS). However, there was no significant difference in serum levels of glucose, insulin, total oxidants (TOS) and liver TOS between the M0L group and groups C and L. Also, insulin levels of M12L significantly increased, compared to the M6L group. Biochemical results, which were confirmed by histopathology, indicate that administering OIE after 6 hours and immediately after taking M may markedly prevent PβCI, hyperglycemia and OS. In addition, OIE's effectiveness decreased after 6 hours and was totally ineffective after 12 hours. We concluded that OIE may help to achieve a better prognosis and reduce mortality rate in cases presented to the emergency department, particularly within the first 6 hours, resulting from organophosphate pesticide poisoning by oral ingestion.

KEYWORDS:

Malathion; oral intralipid emulsion; organophosphate intoxication; pancreatic β-cell injury

PMID:
24180244
DOI:
10.3109/01480545.2013.838780
[Indexed for MEDLINE]

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