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BMC Pediatr. 2013 Nov 4;13:178. doi: 10.1186/1471-2431-13-178.

Early feeding of fortified breast milk and in-hospital-growth in very premature infants: a retrospective cohort analysis.

Author information

1
Department of Neonatology, University Children's Hospital Tübingen, Calwerstr, 7, Tuebingen 72076, Germany. Axel.Franz@med.uni-tuebingen.de.

Abstract

BACKGROUND:

Fortified human milk may not meet all nutritional needs of very preterm infants. Early transition from complementary parenteral nutrition to full enteral feeds might further impair in-hospital growth. We aimed to investigate the impact of the cumulative intake of fortified human milk on early postnatal growth in a cohort of very low birth weight infants after early transition to full enteral feeds.

METHODS:

Retrospective single-centre observational study. Data are presented as median (interquartile range).

RESULTS:

N  =  206 very preterm infants were analysed (gestational age at birth 27.6 (25.6-29.6) weeks, birth weight 915 (668-1170) g). Full enteral feeds were established at postnatal day 8 (6-10) and adequate postnatal growth was achieved (difference in standard deviation score for weight from birth to discharge -0.105(-0.603 - -0.323)). Standard deviation score for weight from birth to day 28 decreased more in infants with a cumulative human milk intake > 75% of all enteral feeds (-0.64(-1.08 - -0.34)) compared to those with < 25% human milk intake (-0.41(-0.7 - -0.17); p  =  0.017). At discharge, a trend towards poorer weight gain with higher proportions of human milk intake persisted. In contrast, we observed no significant difference for head circumference growth.

CONCLUSIONS:

Our current standardized fortification of human milk may not adequately support early postnatal growth.

PMID:
24180239
PMCID:
PMC4228390
DOI:
10.1186/1471-2431-13-178
[Indexed for MEDLINE]
Free PMC Article
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