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Nature. 1978 Feb 16;271(5646):618-21.

Structural evidence for gene duplication in the evolution of the acid proteases.

Abstract

X-ray studies of acid proteases indicate a bilobal structure with a well defined active site cleft. An intramolecular twofold symmetry axis relates two topologically similar domains and the active site residues. A possible mechanism for evolution by gene duplication, divergence and gene fusion is presented.

PMID:
24179
DOI:
10.1038/271618a0
[Indexed for MEDLINE]

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