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Oncoimmunology. 2013 Aug 1;2(8):e25475. Epub 2013 Jul 1.

Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells.

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Department of Molecular Microbiology and Immunology; Norris Comprehensive Cancer Center; Keck School of Medicine; University of Southern California; Los Angeles, CA USA.


The CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. However, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. Humanizing mice with respect to the CD1d/NKT antigen presentation system will provide a tool to identify novel lipids that exert antineoplastic functions by targeting NKT cells before the initiation of costly and lengthy clinical trials.


CD1d; anticancer therapy; humanized mice; iNKT cells; immunotherapy

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