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Pediatr Blood Cancer. 2014 Apr;61(4):749-52. doi: 10.1002/pbc.24778. Epub 2013 Oct 31.

Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: a children's oncology group study.

Author information

1
Department of Pediatrics, Division of Pediatric Hematology/Oncology, Vanderbilt University, Nashville, TN, Tennessee.

Abstract

To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P < 0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P < 0.001). IGFBP-2 did not correlate with age (P = 0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P < 0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.

KEYWORDS:

cancer biology; clinical trials; osteosarcoma

PMID:
24178953
PMCID:
PMC3946315
DOI:
10.1002/pbc.24778
[Indexed for MEDLINE]
Free PMC Article
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