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Hippocampus. 2014 Feb;24(2):131-4. doi: 10.1002/hipo.22227. Epub 2013 Nov 26.

Exercise boosts hippocampal volume by preventing early age-related gray matter loss.

Author information

1
RG Animal models in Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim (ZI), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Abstract

Recently, a larger hippocampus was found in exercising mice and men. Here we studied the morphological underpinnings in wheel running mice by longitudinal magnetic resonance imaging. Voxel-based morphometry revealed that running increases hippocampal volume by inhibiting an early age-related gray matter loss. Disruption of neurogenesis-related neuroplasticity by focalized irradiation is sufficient to block positive effects of exercise on macroscopic brain morphology.

KEYWORDS:

aging; brain matter; hippocampus; mice; sports; wheel running

PMID:
24178895
DOI:
10.1002/hipo.22227
[Indexed for MEDLINE]
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