Send to

Choose Destination
See comment in PubMed Commons below
Nat Prod Rep. 2013 Dec;30(12):1527-67. doi: 10.1039/c3np70068b.

History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease).

Author information

  • 1Universit√© de Haute Alsace, Laboratoire de Chimie Organique et Bioorganique, EA4566, Ecole Nationale Sup√©rieure de Chimie de Mulhouse, 3 rue Alfred Werner, 68093 Mulhouse Cedex, France.

Erratum in

  • Nat Prod Rep. 2014 Sep;31(9):1228-9.


Mycobacterium ulcerans infections (Buruli ulcer disease) have a long history that can be traced back 150 years. The successive discoveries of the mycobacteria in 1948 and of mycolactone A/B in 1999, the toxin responsible for this dramatic necrotic skin disease, resulted in a paradigm shift concerning the disease itself and in a broader sense, delineated an entirely new role for bioactive polyketides as virulence factors. The fascinating history, biology and chemistry of M. ulcerans infections are discussed in this review.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Support Center