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J Vestib Res. 2013;23(3):177-86. doi: 10.3233/VES-130483.

Ondansetron reduces lasting vestibular deficits in a model of severe peripheral excitotoxic injury.

Author information

1
Sensorion, Montpellier, France.

Abstract

Vestibular neuritis is a neuroinflammatory, peripheral vestibular pathology leading to chronic deficits and long-term disability. While current corticosteroid-based therapy does not appear to positively influence the long term outcome for the patient, a recent clinical pilot study suggested a functional vestibuloprotective effect of the anti-emetic ondansetron in the treatment of vestibular neuritis. We here demonstrate that systemic post-insult administration of ondansetron in a novel rat model of severe excitotoxic vestibular insult reproduces the clinically demonstrated functional benefits. This ondansetron-conferred reduction of functional deficits stems from the protection of synapses between sensory hair cells and primary neurons from excitotoxically induced lesion.

KEYWORDS:

Vestibule; excitoxicity; functional deficit; neuritis; nystagmus; ondansetron; vertigo

PMID:
24177349
DOI:
10.3233/VES-130483
[Indexed for MEDLINE]

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