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EMBO Rep. 2013 Dec;14(12):1127-35. doi: 10.1038/embor.2013.168. Epub 2013 Nov 1.

Loss of iron triggers PINK1/Parkin-independent mitophagy.

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1
MRC-Protein Phosphorylation and Ubiquitylation Unit, and.

Abstract

In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Iron chelation-induced mitophagy requires that cells undergo glycolysis, but does not require PINK1 stabilization or Parkin activation, and occurs in primary human fibroblasts as well as those isolated from a Parkinson's patient with Parkin mutations. Thus, we have identified and characterized a mitophagy pathway, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.

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PMID:
24176932
PMCID:
PMC3981094
DOI:
10.1038/embor.2013.168
[Indexed for MEDLINE]
Free PMC Article

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