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Neurol Clin. 2013 Nov;31(4):915-28. doi: 10.1016/j.ncl.2013.05.001. Epub 2013 Jul 17.

Clinical neurogenetics: stroke.

Author information

1
Department of Neurology, JP Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA. Electronic address: nrost@partners.org.

Abstract

Understanding the genetic architecture of cerebrovascular disease holds promise of novel stroke prevention strategies and therapeutics that are both safe and effective. Apart from a few single-gene disorders associated with cerebral ischemia or intracerebral hemorrhage, stroke is a complex genetic phenotype that requires careful ascertainment and robust association testing for discovery and validation analyses. The recently uncovered shared genetic contribution between clinically manifest stroke syndromes and closely related intermediate cerebrovascular phenotypes offers effective and efficient approaches to complex trait analysis.

KEYWORDS:

Cerebrovascular disease; Genetics; Genome-wide association study; Intracerebral hemorrhage; Ischemic stroke; Phenotype; Stroke subtype; White matter hyperintensity

PMID:
24176416
PMCID:
PMC3815700
DOI:
10.1016/j.ncl.2013.05.001
[Indexed for MEDLINE]
Free PMC Article

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