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World J Virol. 2013 May 12;2(2):79-90. doi: 10.5501/wjv.v2.i2.79.

Viral manipulation of cellular protein conjugation pathways: The SUMO lesson.

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1
Domenico Mattoscio, Chiara V Segré, Susanna Chiocca, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.

Abstract

Small ubiquitin-like modifier (SUMO)ylation is a key post-translational modification mechanism that controls the function of a plethora of proteins and biological processes. Given its central regulatory role, it is not surprising that it is widely exploited by viruses. A number of viral proteins are known to modify and/or be modified by the SUMOylation system to exert their function, to create a cellular environment more favorable for virus survival and propagation, and to prevent host antiviral responses. Since the SUMO pathway is a multi-step cascade, viral proteins engage with it at many levels, to advance and favor each stage of a typical infection cycle: replication, viral assembly and immune evasion. Here we review the current knowledge on the interplay between the host SUMO system and viral lifecycle.

KEYWORDS:

Exploitation; Immune evasion; Innate immunity; Small ubiquitin-like modifier; Small ubiquitin-like modifier-ylation; Virus; Virus assembly

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