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J Exp Zool B Mol Dev Evol. 2014 Sep;322(6):342-51. doi: 10.1002/jez.b.22542. Epub 2013 Oct 30.

Atypical RNAs in the coelacanth transcriptome.

Author information

1
Department of Computer Science, Bioinformatics Group, University of Leipzig, Leipzig, Germany; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.

Abstract

Circular and apparently trans-spliced RNAs have recently been reported as abundant types of transcripts in mammalian transcriptome data. Both types of non-colinear RNAs are also abundant in RNA-seq of different tissue from both the African and the Indonesian coelacanth. We observe more than 8,000 lincRNAs with normal gene structure and several thousands of circularized and trans-spliced products, showing that such atypical RNAs form a substantial contribution to the transcriptome. Surprisingly, the majority of the circularizing and trans-connecting splice junctions are unique to atypical forms, that is, are not used in normal isoforms.

PMID:
24174405
DOI:
10.1002/jez.b.22542
[Indexed for MEDLINE]

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