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Neurosci Lett. 2014 Apr 17;565:42-6. doi: 10.1016/j.neulet.2013.10.046. Epub 2013 Oct 27.

Dual role of astrocytes in perinatal asphyxia injury and neuroprotection.

Author information

1
Laboratorio de Citoarquitectura y Plasticidad Neuronal, Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Buenos Aires, Argentina.
2
Laboratorio de Citoarquitectura y Plasticidad Neuronal, Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Buenos Aires, Argentina; Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
3
Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
4
Cátedra de Farmacología, Facultad de Medicina-UBA and CEFYBO-UBA-CONICET, Argentina.
5
Institute for Medical Biochemistry and Molecular Biology Universitätsmedizin Greifswald Ernst-Moritz Arndt-Universität Greifswald, Germany.
6
Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Facultad de Psicología, Universidad de Málaga, Campus de Teatinos s/n, 29071 Málaga, Spain; Departament de Pedagogia i Psicologia, Facultat de Ciències de l'Educació, Universitat de Lleida. Av. de l'Estudi General, 4, 25001, Lleida, Spain.
7
Laboratorio de Citoarquitectura y Plasticidad Neuronal, Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini" (ININCA), UBA-CONICET, Marcelo T. de Alvear 2270, C1122AAJ, Buenos Aires, Argentina; Departamento de Biología Universidad Argentina John F Kennedy, Buenos Aires, Argentina. Electronic address: fcapani@fmed.uba.ar.

Abstract

Perinatal asphyxia represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness. However, at the moment, most of the therapeutic strategies were not well targeted toward the processes that induced the brain injury during perinatal asphyxia. Traditionally, experimental research focused on neurons, whereas astrocytes have been more related with the damage mechanisms of perinatal asphyxia. In this work, we propose to review possible protective as well as deleterious roles of astrocytes in the asphyctic brain with the aim to stimulate further research in this area of perinatal asphyxia still not well studied.

KEYWORDS:

Astrocytes; Cell death; Neuroprotection; Perinatal asphyxia; Redox signaling

PMID:
24172702
DOI:
10.1016/j.neulet.2013.10.046
[Indexed for MEDLINE]

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