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J Hum Hypertens. 2014 May;28(5):323-7. doi: 10.1038/jhh.2013.103. Epub 2013 Oct 31.

The relationship of brachial-ankle pulse wave velocity to future cardiovascular disease events in the general Japanese population: the Takashima Study.

Author information

1
Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
2
1] Department of Health Science, Shiga University of Medical Science, Shiga, Japan [2] Department of Medicine, University of Calgary, Calgary, AB, Canada.
3
1] Department of Health Science, Shiga University of Medical Science, Shiga, Japan [2] Office for Research Ethics & Bioethics, National Cerebral and Cardiovascular Center, Osaka, Japan.
4
1] Department of Health Science, Shiga University of Medical Science, Shiga, Japan [2] Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan.
5
1] Department of Health Science, Shiga University of Medical Science, Shiga, Japan [2] Course for Nurse Teachers, Osaka Kyoiku University, Osaka, Japan.
6
Takashima City Hospital, Shiga, Japan.
7
Makino Hospital, Shiga, Japan.
8
Otsu Red Cross Hospital, Shiga, Japan.
9
Shiga Medical Center for Adults, Shiga, Japan.
10
Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Aichi, Japan.
11
1] Department of Health Science, Shiga University of Medical Science, Shiga, Japan [2] Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Shiga, Japan.

Abstract

Brachial-ankle pulse wave velocity (baPWV) is a non-invasive measure of arterial stiffness obtained using an automated system. Although baPWVs have been widely used as a non-invasive marker for evaluation of arterial stiffness, evidence for the prognostic value of baPWV in the general population is scarce. In this study, we assessed the association between baPWV and future cardiovascular disease (CVD) incidence in a Japanese population. From 2002 to 2009, baPWV was measured in a total of 4164 men and women without a history of CVD, and they were followed up until the end of 2009 with a median follow-up period of 6.5 years. Hazard ratios (HRs) for CVD incidence according to baPWV levels were calculated using a Cox proportional hazards model adjusted for potential confounding factors, including seated or supine blood pressure (BP). During the follow-up period, we observed 40 incident cases of CVD. In multivariable-adjusted model, baPWV as a continuous variable was not significantly associated with future CVD risk after adjustment for supine BP. However, compared with lower baPWV category (<18 m s(-1)), higher baPWV (< or = 18.0 m s(-1)) was significantly associated with an increased CVD risk (HR: 2.70, 95% confidence interval: 1.18-6.19). Higher baPWV (< or = 18.0 m s(-1)) would be an independent predictor of future CVD event in the general Japanese population.

PMID:
24172293
DOI:
10.1038/jhh.2013.103
[Indexed for MEDLINE]
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