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ACS Appl Mater Interfaces. 2013 Nov 27;5(22):11900-5. doi: 10.1021/am4035762. Epub 2013 Nov 13.

Porous surface structure fabricated by breath figures that suppresses Pseudomonas aeruginosa biofilm formation.

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Graduate School of Science and Technology, School of Integrated Design Engineering, Keio University , 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.


As colonizers of medical-device surfaces, Pseudomonas aeruginosa strains present a serious source of infection and are of major concern. In this study, we fabricated films with porous surfaces by breath figures that disturb mergence by bacterial attachment, thereby impeding biofilm development. Previous studies have shown that microtopography prevents the development of P. aeruginosa biofilms. Accordingly we indented surfaces with patterns of micrometer-sized pores using breath figures at ordinary temperatures and pressures. The antimicrobial effect of surface figures was experimentally investigated by controlling the surface structure. The results suggested that pores of 5-11 μm in diameter effectively inhibit bacterial activity. It appears that biofilm development is precluded by the decreased contact area between the films and bacteria.

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