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J Antibiot (Tokyo). 2014 Feb;67(2):171-4. doi: 10.1038/ja.2013.104. Epub 2013 Oct 30.

Pimarane diterpenes from the Arctic fungus Eutypella sp. D-1.

Author information

1
College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China.
2
1] College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China [2] School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
3
School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.

Abstract

Two new diterpenes, libertellenone G(1) and libertellenone H(2) were isolated from the fungus Eutypella sp. D-1 isolated from the soil of high latitude of Arctic, together with two known pimarane diterpenes (3-4). The structures of 1 and 2 were elucidated from spectroscopic data (nuclear magnetic resonance, mass spectrometry and infrared). These compounds were evaluated for cytotoxic activity against seven human tumor cell lines. Compound 2 showed a range of cytotoxicity between 3.31 and 44.1 μM. Compound 1 exhibited antibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.

PMID:
24169793
DOI:
10.1038/ja.2013.104
[Indexed for MEDLINE]
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