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Br J Cancer. 2014 Feb 4;110(3):808-16. doi: 10.1038/bjc.2013.686. Epub 2013 Oct 29.

Choline and betaine intakes are associated with reduced risk of nasopharyngeal carcinoma in adults: a case-control study.

Author information

1
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
2
1] Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China [2] Tactic Training Section of Criminal Investigation, Guangdong Provincial Security Department, Guangzhou 510050, China.
3
1] Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China [2] Information Section, Central Hospital of Panyu District, Guangzhou 511400, China.
4
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
5
Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
6
Sun Yat-sen University Ophthalmic Center, Guangzhou 510060, China.

Abstract

BACKGROUND:

Intakes of choline and betaine have been inversely related to the risk of various neoplasms, but scant data exist on nasopharyngeal carcinoma (NPC). We examined the association between consumption of choline and betaine and risk of NPC.

METHODS:

We conducted a case-control study with 600 incident NPC patients and 600 controls 1 : 1 matched by age, sex and household type in Guangdong, China. Dietary intake was assessed by a food frequency questionnaire through face-to-face interview.

RESULTS:

Intakes of total choline, betaine and choline+betaine were inversely related to NPC after adjustment for various lifestyle and dietary factors (all P-trend <0.001). Adjusted odds ratios (95% CI) for quartile 4 (vs quartile 1) were 0.42 (0.29, 0.61) for total choline, 0.50 (0.35, 0.72) for betaine and 0.44 (0.30, 0.64) for betaine+total choline. Regarding various sources of choline, lower NPC risk was associated with greater intakes of choline from phosphatidylcholine, free choline, glycerophosphocholine and phosphocholine, but not sphingomyelin.

CONCLUSION:

These findings are consistent with a beneficial effect of choline and betaine intakes on carcinogenesis.

PMID:
24169354
PMCID:
PMC3915107
DOI:
10.1038/bjc.2013.686
[Indexed for MEDLINE]
Free PMC Article
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