Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes

Epigenetics. 2014 Feb;9(2):186-93. doi: 10.4161/epi.26792. Epub 2013 Oct 29.

Abstract

The MOZ/MORF complexes represent an example of a chromatin-binding assembly whose recruitment to specific genomic regions and activity can be fine-tuned by posttranslational modifications of histones. Here we detail the structures and biological functions of epigenetic readers present in the four core subunits of the MOZ/MORF complexes, highlight the imperative role of combinatorial readout by the multiple readers, and discuss new research directions to advance our understanding of histone acetylation.

Keywords: BRPF; ING5; KAT6A; KAT6B; MORF; MOZ; PHD; acetylation; histone; reader.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylation
  • Animals
  • Epigenesis, Genetic*
  • Histone Acetyltransferases / chemistry
  • Histone Acetyltransferases / genetics
  • Histone Acetyltransferases / metabolism*
  • Humans
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Protein Conformation
  • Protein Multimerization
  • Protein Subunits / chemistry
  • Protein Subunits / metabolism
  • Zinc Fingers

Substances

  • Nuclear Proteins
  • Protein Subunits
  • Histone Acetyltransferases
  • KAT6A protein, human
  • KAT6B protein, human