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F1000Prime Rep. 2013 Oct 1;5:42. doi: 10.12703/P5-42.

Intensive risk factor control in stroke prevention.

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Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University 1400 Western Road, London, ON, N6G 2V2 Canada.


Stroke prevention is an urgent priority because of the aging of the population and the steep association of age and risk of stroke. Direct costs of stroke are expected to more than double in the US between 2012 and 2030. By getting everything right, patients can reduce the risk of stroke by 80% or more; however, getting everything right is a tall order. Roughly in order of importance, this requires smoking cessation, maintenance of a healthy weight, a Cretan Mediterranean diet, blood pressure control, lipid-lowering drugs, appropriate use of antiplatelet agents and anticoagulants, and appropriate carotid endarterectomy and stenting. A new approach called "treating arteries instead of targeting risk factors" appears promising but requires validation in randomized trials.

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