Send to

Choose Destination
Ther Adv Psychopharmacol. 2013 Oct;3(5):272-4. doi: 10.1177/2045125313484323.

Clozapine for self-injurious behavior in individuals with borderline personality disorder.

Author information

Central Regional Hospital, 300 Veazey Road, Butner, NC 27509, USA.


Prior reports suggest that clozapine can markedly reduce aggression and self-injurious behavior in patients with borderline personality disorder (BPD). We present a series of four patients with BPD and persistent self-injurious behavior treated with clozapine at a state psychiatric hospital. After treatment with clozapine these patients ceased self-injurious behaviors and aggression, and no longer required intensive levels of observation or restrictive procedures. All were successfully discharged from the hospital soon after initiation of clozapine. Clozapine appears to be efficacious in the management of chronic suicidality, self-injurious behaviors and aggression in patients with severe BPD.


Borderline personality disorder; aggression; clozapine; suicide

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center