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Acta Inform Med. 2013;21(3):205-7. doi: 10.5455/aim.2013.21.205-207.

P300 wave changes in patients with multiple sclerosis.

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School of medicine, University of Split, Croatia.



In patients with multiple sclerosis among other symptoms occur cognitive dysfunctions, which can be shown by P300 wave changes.


The aim of this study was to demonstrate that patients with multiple sclerosis have reduced amplitude and prolonged latency, longer than 300 ± 10 ms.


The study included group of patients with multiple sclerosis and control group. After reviewing the medical records both groups of 14 participants were subjected to the same testing procedures auditory cognitive potentials (P300).


We have shown that patients with multiple sclerosis don't have prolonged P300 target stimulus latency, but they have a longer P300 frequent stimulus latency for 18 ms. From 14 patients seven had a pathological P300 target stimulus amplitude, and even 12 patient had pathological P300 frequent stimulus amplitude.


People with multiple sclerosis have altered P300 which indicates the presence of cognitive dysfunction in these patients.


P300; auditory brain stem evoked potentials; cognitive impairment.; multiple sclerosis

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