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Dis Markers. 2013;35(2):129-34. doi: 10.1155/2013/279046. Epub 2013 Aug 7.

COMT-Val158Met-polymorphism is not a risk factor for acute kidney injury after cardiac surgery.

Author information

1
Klinik fuer Herz- und GefaeƟchirurgie, Deutsches Herzzentrum Muenchen, Technische Universitaet Muenchen, Munich Heart Alliance, Lazarettstrasse 36, 80636 Munich, Germany.

Abstract

BACKGROUND:

Cardiac surgery-associated acute kidney injury (CSA-AKI) depicts a major complication after cardiac surgery using cardiopulmonary bypass (CPB).

OBJECTIVE:

CSA-AKI has clearly been linked to increased perioperative morbidity and mortality. Dysregulations of vasomotor tone are assumed to be causal for CSA-AKI. While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Pilot studies found associations between those COMT genotypes and CSA-AKI.

METHODS:

We prospectively included 1741 patients undergoing elective cardiac surgery using cardiopulmonary bypass (CPB). Patients were genotyped for COMT-Val158Met-(G/A) polymorphism (rs4680).

RESULTS:

Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between COMT genotypes and the RIFLE criteria could be detected. A multiple linear regression analysis for postoperative creatinine increase revealed highly significant associations for aortic cross-clamp time (P < 0.001), CPB time (P < 0.001), norepinephrine (P < 0.001), and age (P < 0.001). No associations were found for COMT genotypes or baseline creatinine. With an R (2) = 0.39 and a sample size of 1741, the observed power of the regression analysis was >99%.

CONCLUSIONS:

Based on our results, we can rule out an association between the COMT-Val158Met-(G/A) polymorphism and the appearance of CSA-AKI.

PMID:
24167357
PMCID:
PMC3774963
DOI:
10.1155/2013/279046
[Indexed for MEDLINE]
Free PMC Article

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