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Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19054-8. doi: 10.1073/pnas.1317561110. Epub 2013 Oct 28.

Transplantation of human islets without immunosuppression.

Author information

1
Department of Medicine III and Department of Visceral, Thorax, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.

Abstract

Transplantation of pancreatic islets is emerging as a successful treatment for type-1 diabetes. Its current stringent restriction to patients with critical metabolic lability is justified by the long-term need for immunosuppression and a persistent shortage of donor organs. We developed an oxygenated chamber system composed of immune-isolating alginate and polymembrane covers that allows for survival and function of islets without immunosuppression. A patient with type-1 diabetes received a transplanted chamber and was followed for 10 mo. Persistent graft function in this chamber system was demonstrated, with regulated insulin secretion and preservation of islet morphology and function without any immunosuppressive therapy. This approach may allow for future widespread application of cell-based therapies.

KEYWORDS:

immune barrier; oxygenation; β-cell replacement

PMID:
24167261
PMCID:
PMC3839710
DOI:
10.1073/pnas.1317561110
[Indexed for MEDLINE]
Free PMC Article

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