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Head Neck. 2014 Dec;36(12):1727-31. doi: 10.1002/hed.23524. Epub 2014 Jan 29.

Time trends in T3 to T4 laryngeal cancer: a population-based long-term analysis.

Author information

1
Department of Oncology, Örebro University Hospital, Örebro, Sweden.

Abstract

BACKGROUND:

A decline in laryngectomies and survival in laryngeal cancer has been reported, especially among patients with advanced tumors.

METHODS:

Of 1058 patients with laryngeal cancer diagnosed from 1978 to 2007 in the Uppsala-Örebro region in Sweden, 263 T3 to T4 tumors treated with curative intent were studied retrospectively. Two time periods were defined, 1978 to 1992 and 1993 to 2007.

RESULTS:

Glottic tumors decreased constituting 68.6% of cases in 1978 to 1992 and 47.9% in 1993 to 2007. Laryngectomies were performed in 38.8% and 34.5% in the corresponding time periods. The use of laryngectomy was not strongly prognostic. A decline in overall survival (OS) over time could only be identified for the first year of follow-up. Chemotherapy was only used in a minority of cases.

CONCLUSION:

The marked decrease of glottic site may mark a shift in etiology. Laryngectomy was not strongly associated with improved survival. The absence of improved survival calls for intensified research.

KEYWORDS:

cancer; glottic; laryngeal; laryngectomy; supraglottic

PMID:
24166872
DOI:
10.1002/hed.23524
[Indexed for MEDLINE]

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