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Dev Dyn. 2014 Mar;243(3):497-508. doi: 10.1002/dvdy.24085. Epub 2013 Dec 2.

Embryonic expression of the transforming growth factor beta ligand and receptor genes in chicken.

Author information

1
Molecular Cardiovascular Research Program, Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona.

Abstract

BACKGROUND:

Transforming growth factor-beta (TGFβ) signaling regulates a myriad of biological processes during embryogenesis, in the adult, and during the manifestation of disease. TGFβ signaling is propagated through one of three TGFβ ligands interacting with Type I and Type II receptors, and Type III co-receptors. Although TGFβ signaling is regulated partly by the combinatorial expression patterns of TGFβ receptors and ligands, a comprehensive gene expression analysis has not been published.

RESULTS:

Here we report the embryonic mRNA expression patterns in chicken embryos of the canonical TGFβ ligands (TGFB1, TGFB2, and TGFB3) and receptors (TGFBR1, TGFBR2, TGFBR3), plus the Activin A receptor, type 1 (ACVR1) and co receptor Endoglin (ENG) that also transduce TGFβ signaling.

CONCLUSIONS:

TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures. Integrating expression information identifies combinations of ligands and receptors that are involved in specific developmental processes including somitogenesis, cardiogenesis and vasculogenesis.

KEYWORDS:

Gallus gallus; chicken; in situ hybridization; transforming growth factor beta

PMID:
24166734
PMCID:
PMC3969743
DOI:
10.1002/dvdy.24085
[Indexed for MEDLINE]
Free PMC Article

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