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Neuropediatrics. 2013 Dec;44(6):297-301. doi: 10.1055/s-0033-1358602. Epub 2013 Oct 28.

Role of autoantibodies in acquired inflammatory demyelinating diseases of the central nervous system in children.

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1
Division of Pediatric Neurology, Department of Pediatrics I, Innsbruck Medical University, Innsbruck, Austria.

Abstract

The recent detection of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) autoantibodies in acquired inflammatory demyelinating diseases, such as neuromyelitis optica, or acute disseminated encephalomyelitis, and multiple sclerosis, in children strongly indicates that B-cell-dependent mechanisms contribute to the pathogenesis. This review aims to give an overview of the role of autoantibodies in inflammatory demyelinating pediatric diseases, with a focus on antibodies to AQP4 and MOG.

PMID:
24166146
DOI:
10.1055/s-0033-1358602
[Indexed for MEDLINE]

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