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Electrophoresis. 2014 May;35(9):1275-84. doi: 10.1002/elps.201300415. Epub 2013 Nov 29.

Microfluidic chip-based liquid chromatography coupled to mass spectrometry for determination of small molecules in bioanalytical applications: an update.

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1
Department of Chemistry, Soochow University, Taipei, Taiwan.

Abstract

Many microfluidic chip-based LC-MS systems have been utilized for high-throughput analysis in various fields of bioanalytical applications such as proteomic, glycomic, pharmaceutical, and clinical research. This review is an update of a previous review article (Electrophoresis 2012, 33, 635-643) to mainly cover the most recent advancements in chip-based LC-MS for determining small molecules in bioanalysis. First, the different types of microfluidic chip devices for chip-based LC-MS analysis will be discussed. Following the discussion of the recent developments in the chip-based instrumentation, the applications of chip-based LC-MS for determining small molecules, such as glycans, pharmaceutical drugs, drugs of abuse, drug metabolites, and biomarkers in various biological sample matrixes will also be included in this review.

KEYWORDS:

Bioanalytical applications; Chip-based LC-MS; MS/MS

PMID:
24165927
DOI:
10.1002/elps.201300415
[Indexed for MEDLINE]
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