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Am J Alzheimers Dis Other Demen. 2014 Mar;29(2):159-65. doi: 10.1177/1533317513507373. Epub 2013 Oct 27.

Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease.

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  • 11Department of Neurosciences, University of California, San Diego, CA, USA.

Abstract

BACKGROUND:

To assess the relationship between regional neocortical atrophy and psychotic symptoms in adults with mild cognitive impairment (MCI) and Alzheimer's disease (AD).

METHODS:

Rates of change in regional neocortical atrophy as measured by longitudinal magnetic resonance imaging scans and the occurrence of psychotic symptoms and/or the long-term use of antipsychotic medications in 389 outpatients with MCI or AD in Alzheimer's Disease Neuroimaging Initiative.

RESULTS:

Atrophy rate of 3 specific neocortical regions, lateral frontal, lateral parietal, and anterior cingulate gyrus, was significantly associated with the onset of psychosis including delusions, agitation, wandering, and hallucinations and/or the need for chronic antipsychotic medications. Atrophy rate of the lateral frontal lobe correlated most significantly with onset of psychotic symptoms or need for chronic antipsychotic medications.

CONCLUSIONS:

Psychosis was associated with volume loss in specific regions of the lateral frontal and parietal lobes as well as anterior cingulate gyrus.

KEYWORDS:

Alzheimer’s disease; dementia; neuroimaging; psychosis

PMID:
24164929
DOI:
10.1177/1533317513507373
[PubMed - indexed for MEDLINE]
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