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Int J Rheum Dis. 2013 Oct;16(5):578-82. doi: 10.1111/1756-185X.12133. Epub 2013 Jun 20.

Effects of sesame seed supplementation on clinical signs and symptoms in patients with knee osteoarthritis.

Author information

1
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

AIM:

Up to now there have been no human studies to evaluate the effect of sesame (Sesamum indicum L.) in osteoarthritis patients; this study was designed to assess the effect of administration of sesame on clinical signs and symptoms in patients with knee osteoarthritis (OA).

METHODS:

Fifty patients with knee OA referred to the only specialty and subspecialty orthopedic centers in the north-west of Iran, were selected and divided into two groups, namely control and sesame groups. Twenty-five patients in the control group received standard treatment while 25 patients in the sesame group received 40 g/day sesame by oral administration during 2 months of the study along with standard drug therapy. The KOOS Questionnaire, Timed Up and Go (TUG) and Visual Analog Scale (VAS) tests were used for clinical assessments.

RESULTS:

There was significant difference in pain intensity between the two groups (P = 0.004) after treatment. The mean score of the KOOS Questionnaire in both treatment and control groups was significantly increased (P = 0.001 and P = 0.001, respectively) compared with baseline. The mean score of the TUG Questionnaire in both treatment and control groups was significantly decreased (P = 0.001 and P = 0.001, respectively) compared with baseline. There was significant difference in post-treatment scores of the KOOS Questionnaire (P = 0.009) and TUG (P = 0.002) between the two groups.

CONCLUSIONS:

The present study showed a positive effect of sesame in improving clinical signs and symptoms in patients with knee OA and indicated the fact that sesame might be a viable adjunctive therapy in treating OA.

KEYWORDS:

clinical signs; osteoarthritis; sesame

PMID:
24164846
DOI:
10.1111/1756-185X.12133
[Indexed for MEDLINE]

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