Format

Send to

Choose Destination
See comment in PubMed Commons below
FEMS Yeast Res. 2014 Feb;14(1):60-72. doi: 10.1111/1567-1364.12114. Epub 2013 Nov 8.

Cellular redox homeostasis, reactive oxygen species and replicative ageing in Saccharomyces cerevisiae.

Author information

1
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia; Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.

Abstract

Ageing cells undergo changes in redox homeostasis and acquire high levels of reactive oxygen species (ROS). Because accumulation of ROS involves a change in redox state of cells, functions that are involved in setting redox and maintaining redox homeostasis are very relevant to an understanding of the possible roles of redox homeostasis and ROS in ageing. This review discusses these aspects of ROS in relation to replicative ageing in the model organism Saccharomyces cerevisiae, with reference to ROS generated in cells; cellular responses to oxidative stress; and how cells maintain redox homeostasis in different cellular compartments. It also considers when ROS generation begins as cells age, which ROS species are relevant to ageing and which cellular compartments and processes may contribute ROS to the ageing process. The discussion also covers the heterogeneity of cells with respect to ROS accumulation at particular cell ages, and the possibility of testing the oxidative theory of ageing in yeast cells.

KEYWORDS:

reactive oxygen species; redox homeostasis; replicative ageing

PMID:
24164795
DOI:
10.1111/1567-1364.12114
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for Wiley
    Loading ...
    Support Center