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J Clin Periodontol. 2013 Nov;40(11):1025-35. doi: 10.1111/jcpe.12155. Epub 2013 Sep 15.

Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study.

Author information

1
Periodontology Section, Department of Oral Sciences, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium; Periodontology Section, Dentistry, University Hospitals Leuven, Leuven, Belgium; Fund for Scientific Research Flanders (FWO), Brussels, Belgium.

Abstract

AIM:

The aim of this randomized placebo-controlled clinical trial was to evaluate the effects of Lactobacillus reuteri-containing probiotic lozenges as an adjunct to scaling and root planing (SRP).

MATERIAL AND METHODS:

Thirty chronic periodontitis patients were recruited and monitored clinically and microbiologically at baseline, 3, 6, 9 and 12 weeks after therapy. All patients received one-stage full-mouth disinfection and randomly assigned over a test (SRP + probiotic, n = 15) or control (SRP + placebo, n = 15) group. The lozenges were used two times a day for 12 weeks.

RESULTS:

At week 12, all clinical parameters were significantly reduced in both groups, while there was significantly more pocket depth reduction (p < 0.05) and attachment gain (p < 0.05) in moderate and deep pockets; more Porphyromonas gingivalis reduction was observed in the SRP + probiotic group.

CONCLUSIONS:

The results indicate that oral administration of L. reuteri lozenges could be a useful adjunct to SRP in chronic periodontitis.

KEYWORDS:

Lactobacillus reuteri; microbiology; periodontitis; probiotics; scaling and root planing; treatment

PMID:
24164569
PMCID:
PMC3908359
DOI:
10.1111/jcpe.12155
[Indexed for MEDLINE]
Free PMC Article

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